![]() The Ludovico Technique + Brimstone: Mom's Knife overrides Brimstone leaving only the floating knife.The Ludovico Technique + Loki's Horns: Loses Loki's Horns effect Isaac controls only one floating knife.The Ludovico Technique + Lost Contact: Floating knife loses almost all ability to block bullets, with a tiny area around the hilt that can stop shots.The Ludovico Technique + any multi-shot item: Isaac controls a floating knife surrounded by additional rotating knives.Tears stat is ignored and damage is dealt at a rate equivalent of 5 tear delay. The Ludovico Technique: Isaac controls a floating knife that does 2x Isaac's damage.Lost Contact: The knife will block bullets, even when held (similar to Trinity Shield but has a smaller blocking area).Jacob's Ladder: The knife will sometimes generate sparks when hitting an enemy.Invulnerability: Even though the knife cannot be fired, the knife will deal damage while Isaac is invincible.Will not explode while held without throwing and while coming back to the Player after being thrown. Adds +2 damage and the knife explodes on contact, once per throw.Ipecac: Knife turns green and poison monsters that hit it.Holy Light: Holy Light can trigger on both held and thrown knives.Knife hits will frequently spawn a blue fly.Guppy: Knife hits will rarely spawn a blue fly.The flames only shoot when fire button is released.Ghost Pepper: The flames can shoot from Isaac while holding the fire button.Increases the size of both the melee swing and the bone throw, and allows a single melee swing to deal damage to an enemy twice instead of just once. The knife will attach to The Forgotten's bone club, forming a scythe. Fruit Cake: The benefits of fruit cake still occur but are short lived due to the high damage of Mom's knife.Flat Stone: Knife bounces as it flies away from Isaac, each bounce splash causing Isaac's tear damage.Fire Mind: Still applies burning but no longer explodes. ![]() Eye Sore: Will occasionally release 1-3 extra knives when shooting Mom's knife.Explosivo: Regular explosive tears may stick to enemies in contact with the knife.Euthanasia: The knife sometimes deals higher damage, but instant kill ability is overridden.Epic Fetus: Each explosion shoots 10 knives in a circle from the point of impact.Picking up more than 16 knives won't fire more knives but will still modify the angle at which they're shot. Diplopia/ Crooked Penny: Each additional copy of the item will grant an extra knife that fires slightly diagonally from the original one, up to a maximum of 16.C Section: Fetuses hold small knives that spin around them slowly, causing extra damage.Compound Fracture: The knife creates bone shards while in contact with an enemy.The brimstone-knives do not benefit from A Lump of Coal. This effect does not work with Azazel's default mini brimstone. The longer the charge, the more knives are added. Brimstone / Sulfur: Shooting the knife also shoots a barrage of knives that goes across the screen, with each knife doing 80% ( 2x) of Isaac's damage the extra knives do not return.Apple!/ Tough Love: The knife deals increased damage sometimes based on luck.20/20 / Conjoined / The Inner Eye / Mutant Spider: Isaac holds only one, but shoots multiple knives at their typical spread.The knife will not work in challenges with the blindfolded effect.The knife can be fired in any direction if using mouse controls (enabled in options.ini).The knife can be held and fired diagonally as if Isaac was holding Analog Stick.This can be done easily with a controller's analog stick or with Analog Stick. The knife can be held and fired diagonally with frame perfect input.Collecting three items from this set will transform Isaac into his mother. This item belongs to the Yes Mother? set.Further charging only increases its maximum range. The knife damage quickly drops to 2x Isaac's damage when returning regardless of charge state. ![]() The knife deals 2x Isaac's damage when held and 6x damage at about 1/3 of full charge.
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